Pencharz DR, Hanlon P, Chakravartty R, et al. DaTQUANT: The Future of Diagnosing Parkinson Disease. Value of semiquantitative analysis for clinical reporting of 123I–2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane SPECT studies. Söderlund TA, Dickson JC, Prvulovich E, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0. Eur J Nucl Med Mol Imaging. Accurate differentiation of parkinsonism and essential tremor using visual assessment of -FP-CIT SPECT imaging: The -FP-CIT study group. The identified less conservative cut-offs showed higher sensitivity without a measurable reduction in specificity with respect to the arbitrary − 2 z-score.īenamer HTS, Patterson J, Grosset DG, et al. We experimentally demonstrated that different substriatal regions and cut-offs for z-score of SBR should be considered to support the diagnosis of either PD or DLB. Putamen to caudate ratio was accurate to detect PD (especially in early stages) while not DLB patients. The whole putamen (z-score cut-off − 0.96) was the most accurate parameter to support the diagnosis of DLB (sensitivity 0.74, specificity 0.95). Posterior putamen of the most affected hemisphere (MAH) with a z-score cut-off of − 1.27 demonstrated the highest accuracy to differentiate between PD and ET (sensitivity 0.97, specificity 0.94). ROC analysis was used to identify most accurate cut-offs for z-score for striatum and substriatal regions (clinical diagnosis at follow-up as gold standard). Semiquantification was computed by means of Datquant® software which returns measures of striatal SBR and z-scores with respect to 118 healthy volunteers belonging to the Parkinson’s Progression Markers Initiative (PPMI). Two-hundred twenty-five patients undergoing DaT SPECT were enrolled (seventy-five de novo PD, eighty ET, fifty DLB, and twenty AD). We aimed to experimentally identify the most accurate z-score cut-offs for SBR of striatal and substriatal regions to independently discriminate PD and DLB, with respect to essential tremor (ET) and Alzheimer’s disease (AD) respectively. So, an IQ of 95 lies one standard deviation below the mean.A cut-off of -2 z-score for striatal or putaminal SBR has been to date arbitrarily used to define an abnormal DaT SPECT in patients with suspected neurodegenerative parkinsonism. Since it's negative, that means the value lies below the mean. We can be even more specific by taking into account the sign. Since a z-score tells us the number of standard deviations a value is from the mean, we can interpret this to mean that an IQ of 95 is one standard deviation from the mean.
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